Compassion and the city is an unusual coupling in the urban analytic. The five essays in this Interventions collection propose compassion in the city as a form of life embedded in the conditions of the urban. Posed against the grain of extant scholarship that addresses these concerns in terms of discursive care or aid, this collection brings in five urban contexts—Dhaka, Delhi, Cairo, Jakarta and Horsens—to highlight understated nuances of how compassion might be recognized and understood within the urban condition. This introduction proposes what embedding compassion as a resolute part of the urban social infrastructure could entail and what that might imply in framing human affirmation in the face of urban suffering.